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For example: T 1/2 digoxin 165 hours, sulfalene 65 hours, ampicillin 1 hour, acetylcholine, epinephrine 2-3 minutes. Many factors influence the release of drugs, including molecular weight, concentration of a substance in blood and urine, pKa, solubility in water and lipids, pH of urine, renal and hepatic blood flow, etc. In cases where a drug is bound to a protein, it cannot be filtered in the renal glomeruli, since their integral molecular weight (m.m.) is more than 70,000. Only those substances are filtered in the renal glomeruli, m.m. With an increase in the pH of urine (urine becomes more alkaline), acidic substances are ionized and are better excreted from the body, and preparations with the properties of bases undergo less ionization, become lipophilic more easily and their reabsorption increases. Water-soluble (hydrophilic) substances and their metabolites are Buy Arimidex (Anastrozole) excreted 1mg online - Women'Buy Arimidex (Anastrozole) 1mg online - Women's Health s Health (eliminated) (from Latin eliminare - to expel) mainly by the kidneys. In case of poisoning, to accelerate the removal of a toxic substance from the body, it is necessary to increase diuresis by introducing diuretics. Gaseous and volatile substances (ether, chloroform, ethanol) are released through ...

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Doses are set experimentally in animals and tested in two or more animal species. Doses that significantly exceed the maximum therapeutic and cause the death of experimental animals (lethal outcome) are called lethal. In experimental medicine, there is the concept of "range of lethal doses" - the range of high doses within which a lethal outcome can develop. Dose designations: LD 20 , LD 50 , LD 75 , LD 100 , subscript 20, 50, 75, 100 - the percentage of animals who died in the experiment after taking a specific dose of the substance. Therapeutic breadth of action - the range of doses from the minimum to the maximum therapeutic, within which the effectiveness and safety Buy Augmentin (Amoxicillin / Clavulanate of ) 250/125mg, 500/125mg, 750/250mg, 875/125mg online - Antibiotics drug treatment are ensured. It is clear that the greater ) Antibiotics Buy (Amoxicillin Clavulanate 875/125mg 500/125mg, 250/125mg, online 750/250mg, / Augmentin the - therapeutic breadth, the safer the drug and the more opportunities to regulate the drug dosing regimen (and vice versa). When studying new pharmacological preparations on animals, an experimental indicator is determined - the therapeutic index (TI). TI - the ratio of doses, in the numerator the dose that causes the death of 50% of the ...

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Clear ideas about the types of drug interactions make it possible to achieve the desired therapeutic effect, to correct undesirable consequences for the patient. When ingested by online - 500mg Buy (Sulfasalazine) health General Azulfidine a patient, they can undergo pharmacological interactions in the course of pharmacokinetics and pharmacodynamics. PHARMACODYNAMIC INTERACTIONS OF DRUGS The interaction occurs at the stage of development of the pharmacological effect. As a result of the pharmacodynamic interaction of medicinal substances, the spectrum or severity of the main or side pharmacological effects of the interaction substances changes mutually (unilaterally). Pharmacodynamic interaction can be observed between drugs of one or more pharmacological groups. The results of the interaction of drugs manufactured under different brand names correspond to the results of the interaction between specific medicinal substances that are part of them. The results of the interaction of medicinal substances from different pharmacological groups are associatively transferred to their pharmacological groups, in which they are combined according to the proximity of the chemical structure, mechanism or spectrum of pharmacological action. Pharmacodynamic interaction of medicinal ...

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Drug-induced parkinsonism is a kind of "parkinsonism syndrome", manifested by a disorder of the extrapyramidal system. It develops with prolonged use of drugs, the mechanism lies in blocking D 2 dopamine receptors in the substantia nigra or in increasing the activity of cholinergic neurons in the neostriatum. Most often, drug parkinsonism occurs with long-term use of typical antipsychotics, derivatives of phenothiazine and butyrophenone. Elimination of these extrapyramidal disorders is possible with the use of only central anticholinergic drugs. The most common manifestations of pathology: rigidity (from the Greek rigidus - hard, inflexible) - sharply increased muscle tone; tremor (from Latin tremor - trembling) - constant involuntary trembling; hypokinesia (from Greek Hypo - under, below, kinesis - movement) - stiffness of movements. That is why, for the treatment of parkinsonism, dopaminergic effects should be increased or cholinergic effects on the subcortical structures that regulate muscle tone should be weakened. Groups of antiparkinsonian drugs: Central anticholinergics (inhibit cholinergic transmission) - trihexyphenidyl, biperiden. Dopaminergic agents (stimulate dopaminergic transmission): - dopamine precursors - levodopa; - combined preparations with levodopa - ...

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Analeptics (analeptics) are divided into two groups: direct action and reflex action. Analeptics of direct action These include camphor, sulphocamphocaine ? They differ from each other in the degree of rewarding influence on the respiratory and vasomotor centers. Camphor in medical practice is used Buy Cycrin (Medroxyprogesterone ) 5mg, 10mg online - Women's Health in the form of dextrorotatory natural camphor obtained from camphor wood or camphor basil. The works of domestic scientists have proved that natural camphor for medical use can be replaced by levorotatory synthetic camphor, since levorotatory and dextrorotatory camphor are similar in pharmacological properties. When applied topically, camphor has an irritating and antiseptic effect. In (Medroxyprogesterone - Cycrin Buy ) 5mg, online Health 10mg Women's neurasthenic conditions, camphor can have a calming effect. Camphor is prescribed as an aphrodisiac in cases of depression of cardiac activity, vasomotor and respiratory centers, poisoning with narcotic and hypnotic drugs, and locally as an irritant. and procaine, the drug is close to camphor in terms of pharmacological effect, but due to solubility in water, it is rapidly absorbed when administered subcutaneously and intramuscularly. According to the chemical ...

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In rheumatic diseases, the course of treatment depends on the effectiveness of therapy and the nature of the disease. With a long course of treatment, the dose must be adjusted every 2-3 weeks. In the treatment of pain conditions due to acute inflammatory processes (for example, toothache, myositis, tendonitis), as well as postoperative pain syndromes, the course of treatment is 5 days. For headache and menstrual pain, Etol Fort is prescribed 1-2 tablets per day if necessary, but not more than 3 days. Side effects Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, bleeding/perforation, heartburn, nausea, vomiting, 50mg, 150mg, (Fluconazole) Women's hematemesis Diflucan Health 100mg, 200mg online Buy -, glossitis, ulcer (gastric/duodenal) with or without bleeding and/or perforation, gastritis, melena, thirst, dry mouth, ulcerative stomatitis, anorexia, belching, Buy Diflucan (Fluconazole) 50mg, 100mg, 150mg, 200mg online - Women's Health increased activity of liver enzymes, cholestatic hepatitis. Contraindications Hypersensitivity to the components of the drug, peptic ulcer of the stomach and duodenum, especially during the period of exacerbation, cytopenia, pregnancy and lactation, childhood, asthma attacks, urticaria, rhinitis or other allergic reactions that are ...

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