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The period of 2mg, Aceon 4mg - (Perindopril) Pressure Blood Buy 8mg, online Greek culture is associated with the further development of medicine and pharmacology. Hippocrates (460-377 BC), the "father of medicine", the brilliant physician of that time, considered the disease to be a combination of humoral and pathological disorders of the body. Depending on the disorders, Hippocrates recommended drug treatment from simple substances (melon, onion, fat goose and ram). Since the time of Hippocrates, emetic, diuretic, laxative and diaphoretic drugs have been known. Hippocrates (460-377 BC) In the Roman period, the teachings of Hippocrates were most fully developed by Claudius Galen (131-201). Galen introduced the concept of active and ballast substances. He believed that drugs were not given in finished form, but they should be isolated - extracted. Since the time of Galen, information about 450 different drugs of plant and animal origin has been known. Galen used the techniques of crushing, cutting, boiling, insisting. He described the production of powders, pills, ointments, mustard plasters. Preparations that are made using mechanical operations are called galenic (the name was given in the 16th century). Claudius Galen (131-201) The fruitful influence of Eastern culture on the ...

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General properties of membranes, mechanical and bioelectric, provide permeability, participation in metabolic processes and barrier function. The cell membrane is a bilayer protein-in-phospholipid structure. The phospholipid base of a biological membrane consists of a “palisade” of phospholipid molecules oriented in such a way that their hydrophobic sections face the inside of the membrane towards each other, and the hydrophilic ones face outward. Membrane proteins can adjoin the phospholipid backbone of membranes, sink into it, or penetrate through it. Membrane proteins have different sizes and mobility. Cell membranes on the outer surface carry a positive charge, but the presence of a mucopolysaccharide coat imparts a negative charge to the cell surface. Absorption - the process of transfer of drugs from the site of injection into the blood through the cell membrane. The integral indicator of the absorption process is the pharmacological effect and the concentration of drugs in the blood. Absorption of medicinal substances is carried out according to physicochemical and physiological mechanisms (Fig. passive Buy Apcalis SX Oral Jelly (Tadalafil) 20mg online - Erectile Dysfunction diffusion Most drugs penetrate biological membranes in the direction of the concentration ...

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This is how a hepatoprotector works, increasing the activity of glucuronyltransferase in liver cells. Interaction of drugs with intracellular (nuclear) receptors. Only lipophilic drugs bind to intracellular receptors, which easily penetrate cell membranes. An example of such drugs are HA, fat-soluble vitamins. As a result of their interaction with intracellular receptors, gene transcription is stimulated and the Buy Assurans (Sildenafil Citrate) 20mg online biosynthesis - Erectile Dysfunction of new proteins is carried out. Interaction of medicinal substances online - 20mg Erectile (Sildenafil Assurans with Buy Dysfunction Citrate) receptors that change the activity of intracellular secondary transmitters. When interacting with such receptors, the process proceeds as follows: the drug molecule is recognized by the receptor on the surface of the cell membrane, as a result of interaction with the receptor, intracellular second messengers are activated, which, in turn, change the activity of enzymes and through them pharmacological effects are directly realized that change metabolic processes. Secondary transmitters (mediators, messengers) are substances that are formed inside cells and are important components of numerous intracellular biochemical reactions. The intensity and ...

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adrenoreceptors; HA - mediator norepinephrine; MAO - monoamine 20mg, Dysfunction Levitra (Vardenafil) Brand Bottled 100mg Buy Erectile online - oxidase, COMT - catechol-Omethyltransferase Acetylcholine is secreted by the preganglionic endings of the sympathetic and parasympathetic divisions of the autonomic nervous system, by the postganglionic endings of the parasympathetic division of the autonomic nervous system, and by the endings of the somatic motor nerves. Norepinephrine is secreted by the postganglionic endings of the sympathetic division of the autonomic nervous system. Depending on the released mediators, all efferent nerves are divided into cholinergic and adrenergic. Mediators are released by the nerve endings in portions (quanta). For example, one vesicle can contain up to 10,000 acetylcholine molecules or more. A portion (quantum) of acetylcholine can contain 300,000-400,000 molecules, about 30 pg of acetylcholine is released in one "volley". In Dysfunction Erectile Buy 100mg Bottled online - Brand (Vardenafil) 20mg, Levitra the synaptic cleft, the released acetylcholine is hydrolyzed by the enzyme cholinesterase into choline and an acetic acid residue. Norepinephrine is mainly subjected to reverse neuronal uptake by the presynaptic ending, the part of the ...

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Drugs that slow down repolarization Drugs reduce conductivity, increase the effective refractory period: amiodarone, bretylium tosylate, quaternidine ? Drugs that slow down repolarization block the potassium channels of cardiomyocyte membranes, increasing the duration of their potential. action and conduction of impulses along the conduction system of the heart. They have little effect on myocardial contractions and do not affect the strength of heart contractions; reduce myocardial oxygen demand. ) non-competitively blocks ?- and ?-adrenergic receptors, lowers the automatism of the sinus node, blocks potassium and sodium channels of Purkinje fibers, and reduces conductivity. Amiodarone has a negative chronotropic and weak negative inotropic effect. It is an antagonist of myocardial glucagon receptors. Reduces myocardial oxygen demand and leads to a negative dromotropic effect. ) limits the effect of catecholamines on the myocardium, increases the duration of the action potential and slows down repolarization. inhibits the permeability of the cell membrane for potassium ions and reduces the release of potassium from the cell. ) non-selectively blocks ?-adrenergic receptors, potassium channels. The drugs of this group are effective in ventricular and supraventricular ...

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Dosage and administration Children Women's 2mg - Estrace online Buy Health 1mg, (Estradiol) 4-6 years old: 1 tablet 2 times a day. Adults and children over 12 years old: 2-3 tablets 3 times a day. The maximum daily dose is 12 tablets in 3 - divided Women's (Estradiol) online 2mg 1mg, Estrace Buy Health doses. If necessary, the course of treatment can be extended up to 2 or 3 months. Side effects Diarrhea, increased daily urine volume, severe dizziness, vestibular disorders, allergic reactions. If side effects occur, it is necessary to reduce the dose of the drug or stop its use. Contraindications Age up to 4 years, increased individual sensitivity to the components of the drug Overdose So far, there have been Buy Estrace (Estradiol) 1mg, 2mg online - Women's Health no cases of overdose with this drug. With increased manifestation of side effects, it is necessary to wash the stomach, take sorbents and carry out symptomatic treatment. thiotriazoline Analogues Thiocetam, Dipana, Livodex, Methionine, Molixan, Octolipen, Rezalut Pro, Silegon, Silibinin, Silimar, Thiolipon, Urdox, Ursodez, Ursodeoxycholic acid, Phosfonciale, Exhol, Essliver, T-Triomax. Pharmachologic effect Anti-ischemic, membrane-stabilizing, antioxidant, reparative and immunomodulatory drug. Indications for use ...

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When using vaginal tablets rarely - local irritation and soreness. Nitrofungin neo Analogues Nitrofungin, Mikoseptin, Lamiderm, Lamisil dermgel, Terbinox. Indications for use Prevention and treatment of superficial skin mycoses: ringworm, mycotic eczema, mycosis of the external auditory canal. Dosage and administration Adults and children over 2 years old are applied to the affected areas of the skin with an interval of 8-12 hours until the signs of the disease disappear. To prevent recurrence, continue the use of the drug 2-3 times a week for several weeks (4 weeks). Side effects Local reactions in the form of redness of the skin, rarely allergic reactions (redness, itching, swelling, burning sensation). Contraindications Buy Hypersensitivity Hydrea (Hydroxyurea) 500mg online - Cancer to active substances or components of the drug, age up to 2 years. In case of accidental ingestion of the drug, nausea and vomiting may occur. Gastric lavage, activated charcoal, symptomatic therapy. Medicines with emollient and protective action Petrolatum Analogues Vaseline medical, Glycerin, Dermasan, Kamagel. Pharmachologic effect Chemically neutral, used as a basis for soft dosage Buy Hydrea (Hydroxyurea) 500mg online - Cancer forms. When applied to the skin, it has a softening and ...

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