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Higher doses for adults under the skin: single - 0.004 g (2 ml of 0.2% solution), daily - 0.012 g (6 ml of 0.2% solution). Release form: powder (for eye drops); eye ointment 3.5%; ampoules of 1 and 2 ml of 0.2% solution for parenteral administration. Higher doses for adults under the skin: single - 0.01 g, daily - 0.02 g.

Release form: 1 ml ampoules of 0.1, 0.25, 0.5 and 1% solution.

Neostigmine methyl sulfate ( Neostigmini methylsulfas ).

Higher doses for adults inside: single - 0.015 g, daily - 0.05 g; under the skin: single - 0.002 g, daily - 0.006 g. Release form: tablets of 0.015 g; ampoules 0.05%, 1 ml. List B Trimedoxime bromide ( Trimedoximi bromidum ).

MEANS BLOCKING CHOLINORECEPTERS (CHOLINOBLOCKERS) Anticholinergic (anticholinergic) are drugs that disrupt or stop the interaction of acetylcholine with cholinergic receptors.

By blocking cholinergic receptors, they reduce or completely eliminate the transmission of excitation from cholinergic nerves to the executive organs, and also reduce the effect of cholinomimetic and anticholinesterase agents. This group of drugs includes blockers of M-cholinergic receptors and H-cholinergic receptors. M-cholinergic blockers include agents that predominantly block M-cholinergic receptors of cells of internal organs. As a result of the blockade, the receptors become less sensitive to the mediator acetylcholine, the influence of the parasympathetic system on the internal organs decreases.

M-anticholinergics are divided into non-selective (block M 1 -, M 2 -, M 3 -cholinergic receptors) and selective (mainly block M 1 - or M 3 Dysfunction 50mg - 100mg, Buy Viagra online Brand Citrate) Erectile (Sildenafil -cholinergic receptors). Non-selective M-anticholinergics Non-selective M-anticholinergics are divided into drugs of plant origin (atropine, platifillin, belladonna preparations Atropa belladonna L ., scopolamine, hyoscine butyl bromide) and synthetic anticholinergics (ipratropium bromide, tiotropium bromide, tropicamide).

M-cholinergic blockers of plant origin Atropine is the main representative of M-cholinergic blockers, found in belladonna, henbane, dope. The main pharmacological property is an antispasmodic effect: the removal of spasms of the smooth muscles of the internal organs. Under the influence of atropine, the tone of the gastrointestinal tract decreases, due to which it is successfully used in the treatment of spasms of the smooth muscles of the stomach and intestines. The secretion of the glands of the gastrointestinal tract is also blocked by atropine, so it and other M-anticholinergics are used for gastric and duodenal ulcers.

With hypersalivation, the secretion of saliva is significantly reduced, causing dry mouth. The action on the ureter is of great importance in the treatment of renal colic (colic - pain caused by spasms of smooth muscles).

It is also used for hepatic colic, as spasmodic bile ducts relax (cholelithiasis). Cholinergic innervation of the bronchi causes increased secretion and contraction of the bronchial muscles.

Atropine blocks the action of cholinergic nerves, weakening the secretion and dilating the bronchi. In this regard, atropine is effective in bronchial asthma.

Atropine causes tachycardia because it blocks the action of the vagus nerve on the heart.

In addition, it improves the conduction of impulses from the atria to the ventricles (atrioventricular conduction). Atropine, due to the blockade of M-cholinergic receptors of the circular muscle of the iris and the ciliary muscle of the ciliary body of the eye, causes pupil dilation and paralysis of accommodation.

When the ciliary muscle relaxes under the influence of atropine, the ligament that supports the lens tenses, the lens becomes less convex and is set to distant vision (accommodation paralysis).

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