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The drug is administered parenterally (intravenously, intramuscularly, subcutaneously) and orally. The onset of the effect and its maximum severity are noted, respectively, after 2-3 minutes and 15-30 minutes after intravenous administration; 15-30 minutes and 30-60 minutes after intramuscular and enteral administration.

Pentazocine causes an increase in pressure in the pulmonary artery, which increases the preload on the heart, increases the work of the heart. That is why the drug is not recommended for use in myocardial infarction. Pentazocine is characterized by dysphoria, hallucinations, tachycardia, and increased blood pressure. The drug is contraindicated in bronchial asthma, traumatic brain injury, epilepsy, cholelithiasis and urolithiasis, liver and kidney failure.

Restrictions on use: pregnancy, breastfeeding, children's age (up to 1 year).

) belongs to the group of agonists-antagonists of opioid receptors (stimulates k-receptors and is an antagonist of ?

Analgesic activity is 5 times greater in relation to morphine.

Used for premedication before surgery, during surgery and for postoperative pain relief.

To a lesser extent than morphine, depresses respiration, less risk of drug dependence. Butorphanol, like pentazocine , increases the 750mg 1000mg, online - Buy Antibiotics Cipro (Ciprofloxacin) 250mg, 500mg, pressure in the pulmonary artery and increases the work of the heart, and therefore it is not recommended for use in myocardial infarction.

It is close to morphine in analgesic activity, but less depresses respiration. Unlike pentazocine and butorphanol, it does not affect hemodynamics; it is used for pain relief in pain syndromes, including myocardial infarction. Analgesics with a mixed mechanism of action (opioid + non-opioid components) Tramadol (Tramal ?

) is a central non-selective ?- , ?- , and k-receptor agonist. The analgesic effect is additionally mediated through the influence on adrenergic and serotonergic transmission (neuronal uptake of norepinephrine and serotonin in the descending antinociceptive pathways is impaired), resulting in increased descending inhibitory effects on the conduction of pain impulses at the level of the spinal cord. The analgesic effect is practically not accompanied by respiratory depression, a decrease in the motility of the gastrointestinal tract, and an increase in the tone of the urinary tract.

Compared to morphine, the drug has a slight narcotic potential (less risk of drug dependence), it is not included in the list of drugs.

The drug is used for postoperative pain and other pain syndromes (with myocardial infarction, malignant tumors, injuries). Antagonists of narcotic analgesics The drugs naloxone (narcan ) and naltrexone block ?

- and k-receptors, therefore, they eliminate the analgesic effect of narcotic analgesics and the euphoria they cause, respiratory depression and other effects. Naloxone is a derivative of phenanthrene, a full competitive antagonist of ? It is administered intravenously in case of intoxication with narcotic analgesics for competitive displacement of them from the connection with the respiratory center. It eliminates not only respiratory depression, but also many other effects of opioid analgesics, including antagonist agonists.

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